Nature study: RNA-triggered CRISPR-Cas12a2 selectively kills cancer cells in cell and mouse models
A Nature study shows that after a research team programmed RNA-guided CRISPR-Cas12a2 to recognize cancer-specific transcripts, it triggered chromatin cleavage, a DNA damage response, and cancer cell death. Secondary reports add p53 mRNA recognition and therapeutic effects in mouse models of lung and liver cancer. All three sources confirm the core mechanism and its potential for selective tumor killing, but some target-combination and model details are described differently across sources, and if a source does not mention them, they cannot be confirmed.