Columbia University team publishes study in Science: key protein synthesis mechanism in E. coli reprogrammed to use only 19 amino acids
Based on cross-checking three sources, a Columbia University team led by Harris Wang published a study in Science that redesigns a key protein-synthesis mechanism in E. coli so its core process uses only 19 amino acids. All three sources confirm the research topic, main organism, and publication venue; on the specific technical path, Source 2 mentions an early test in which isoleucine in 36 essential genes was replaced with valine. Further experimental details, motivation, and full results cannot be confirmed from the provided sources.